Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1)

Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed sonic hedgehog protein (SHH). Dorsally expressed factors, such as members of the bone morphogenic protein and transforming growth factor-beta families, can repress the induction of these neurons.CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival . Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level).