Disabled Homolog 2 Interacting Protein (DAB2IP)

DAB2IP is a Ras GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers.The deduced protein shares significant sequence identity with nGAP (RASAL2). RT-PCR ELISA detected intermediate to high expression in all adult and fetal tissues examined. Highest expression was detected in adult brain, adult kidney, and fetal brain. Within specific adult brain regions, highest expression was detected in cerebellum, hippocampus, caudate nucleus, substantia nigra, and subthalamic nucleus.The deduced 967-amino acid protein has a calculated molecular mass of 110 kD. The N-terminal half of DAB2IP contains a protein kinase C conserved region-2 (C2) domain and a RasGAP domain. The C-terminal half contains a proline-rich region and a leucine zipper domain.