EP300 Interacting Inhibitor Of Differentiation 2 (EID2)
Английские синонимы
CRI2; CREBBP/EP300 Inhibitory Protein 2; CREBBP/EP300 Inhibitor 2; EID-1-like inhibitor of differentiation 2
EID2 may function as an endogenous suppressor of TGF-beta signaling and inhibits differentiation by blocking the histone acetyltransferase activity of p300, class I histone deacetylase, HDACs. The N-terminal portion of EID-2 was required for the binding to HDACs. This region was also involved in the transcriptional repression and nuclear localization, suggesting the importance of the involvement of HDACs in the EID-2 function. EID-2 inhibits TGF-beta/Smad transcriptional responses. EID-2 interacts constitutively with Smad proteins, and most strongly with Smad3. Stable expression of EID-2 in the TGF-beta1-responsive cell line inhibits endogenous Smad3-Smad4 complex formation and TGF-beta1-induced expression of p21 and p15. EID-2 displays developmentally regulated expression with high levels in adult heart and brain.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
