ErbB Receptor Feedback Inhibitor 1 (ERRFI1)

MIG6 is a cytoplasmic protein whose expression is upregulated with cell growth. It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling. The deduced protein contains 462 amino acids and shares significant homology with the rat gene-33 protein product. Epitope-tagged MIG6 showed exclusively cytoplasmic staining following transfection into mouse fibroblasts.In contrast to other mitogen-responsive genes, MIG6 mRNA expression was also regulated during normal cell cycle progression, showing a clear peak around mid-G1. Consistent with cell cycle regulation, terminal differentiation of myeloid leukemia cells to either granulocytic or macrophage-like cells led to clear changes in MIG6 mRNA levels.