FK506 Binding Protein 10 (FKBP10)

FK506 Binding Protein 10 belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase family. It is located in endoplasmic reticulum and acts as molecular chaperones. Two alternatively spliced variants, which encode different isoform, are reported.mouse Fkbp10 is contained within the lumen of the endoplasmic reticulum. Western blot analysis detected expression in 12-day-old mouse aorta, brain, kidney, and lung; no or barely detectable expression was found in adult tissues. Immunolocalization of Fkbp10 in developing lung revealed staining of vascular and airway smooth muscle cells. the human and mouse protein sequences are identical with the exception of a valine-24 addition within the signal sequence of the human protein. Both contain 4 consecutive PPIase domains.