Fc Receptor Like Protein 5 (FCRL5)

Fc receptor-like protein 5 is a protein encoded by the FCRL5 gene.Chromosomal abnormalities involving translocation breakpoints at 1q21-q23 are frequent in B-cell non-Hodgkin lymphoma and multiple myeloma (MM).By cloning the breakpoints of a (1;14)(q21;q32) chromosomal translocation in the FR4 multiple myeloma cell line, followed by exon trapping and screening a spleen cDNA library, Hatzivassiliou et al. (2001) obtained cDNAs encoding 3 isoforms of IRTA1 and 4 isoforms of IRTA2. The 3 major IRTA2 mRNA isoforms (ITRA2A, ITRA2B, and ITRA2C) each have their own unique 3-prime untranslated region, and the proteins they encode share a common amino acid sequence until residue 560, including a signal peptide and 6 extracellular Ig-type domains.