G Protein Coupled Receptor Kinase Interactor 1 (GIT1)

GIT1 contains an ARFGAP domain, Anykrin repeats, and a GRK-interacting domain. The Arf-GAP domain, which enables it to act as a GTPase activating protein (GAP) for the Arf family of GTPases, has been shown to be involved in phosphorylation and inhibition of the ADRB2. If synaptic localization of GIT1 is disturbed, then this is known to affect dendritic spine morphology and formation---this is thought to occur through the Rac1/PAK1/LIMK/CFL1 pathwayThe deduced 770-amino acid protein contains an N-terminal zinc finger-like motif, followed by ankyrin repeats and a C-terminal GRK-interacting domain. Northern blot analysis of rat tissues detected wide expression of a 4.0-kb Git1 transcript, with highest expression in testis and lowest expression in liver and spleen.