G Protein Gamma Transducing Activity Polypeptide 2 (GNgT2)

Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. There is evidence for use of multiple polyadenylation sites by this gene.Phototransduction in the vertebrate rod and cone photoreceptors is regulated by structurally homologous but distinct groups of signaling proteins.GNGT2 is specifically localized in cones, as indicated by immunohistochemical staining. Nucleotide sequence analysis of the gene, designated GNGT2, showed a structure consisting of 3 exons and 2 introns, with the intron splice sites similar to those of the rod G-gamma-1 gene (GNGT1).