Immediate Early Response 3 Interacting Protein 1 (IER3IP1)

By large-scale partial sequencing of a human liver cDNA library and EST database searching, Yiu et al. (2004) identified a novel cDNA encoding a deduced 82-amino acid protein, which they designated immediate-early response-3-interacting protein-1 (IER3IP1).IER3IP1 contains a putative G-patch domain and 2 transmembrane domains. Northern blot analysis revealed a single 1.5-kb transcript expressed at high levels in heart, skeletal muscle, and kidney, moderate levels in liver and brain, and low levels in placenta, lung, and peripheral blood leukocytes. Yiu et al. (2004) found that the IER3IP1 protein localizes to the endoplasmic reticulum through its C-terminal transmembrane domain.