Immunoglobulin Binding Protein 1 (IGBP1)

Immunoglobulin-binding protein 1 is a protein encoded by the IGBP1 gene.The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.Associated to surface IgM-receptor; may be involved in signal transduction. May be involved in regulation of the catalytic activity of type 2A-related serine/threonine phosphatases.Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas.Defects in IGBP1 are the cause of agenesis of the corpus callosum with mental retardation-ocular coloboma-micrognathia (ACCMRCM)