Inhibitor Of Growth Family, Member 2 (ING2)

The deduced 280-amino acid ING1L protein shares 58.9% sequence identity with ING1. ING1L contains a C-terminal PHD-type zinc finger domain. The PHD zinc finger was first identified in 2 closely related plant homeodomain-containing proteins. It is a cys4-his-cys3 (C4HC3)-type motif spanning 50 to 80 amino acids. PHD zinc fingers have been found in a number of proteins implicated in chromatin-mediated transcriptional control.Northern blot analysis of normal human tissues detected ubiquitous expression of 1.3- and 1.5-kb ING1L transcripts. The authors found that ING1L expression was significantly higher in colon tumors than in the adjacent normal colon tissue.