Karyopherin Alpha 5 (KPNa5)

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs).KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. Of the known human importin-alphas, KPNA5 shares the highest sequence identity with SRP1 (KPNA1). Northern blot analysis detected a 2.4-kb KPNA5 transcript only in testis.