Ligand Dependent Nuclear Receptor Corepressor (LCOR)

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box. The deduced 433-amino acid protein contains a DNA-binding motif and a motif conserved in Mlr1 (LCORL).The deduced KIAA1795 protein contains 572 amino acids. RT-PCR followed by ELISA detected highest expression in liver, testis, and ovary, followed by kidney and brain. Within brain, highest expression was detected in amygdala, corpus callosum, and caudate nucleus. The predicted 433-amino acid LCOR protein has a calculated molecular mass of approximately 47 kD. It contains an LxxLL motif, a nuclear localization signal, and a helix-loop-helix domain.