MID1 Interacting Protein 1 (MID1IP1)

MID1IP1 was recently reported to encode for the MID1 interacting G12-like protein involved in Opitz syndrome, a heterogeneous disorder with X-linked and autosomal forms. Functionally, MID1IP1 cooperates with MID1 to stabilize microtubules.Aura affects several events during early development that may be dependent on cytoskeletal rearrangements and it encodes MID1ip1. Cell biology, genetic, and other experimental approaches were used to characterize the aura /MID1ip1 gene function. Together, these studies will contribute to understanding the function and regulation of aura /MID1ip1 during cortical granule exocytosis, cytokinesis and germ plasm segregation.