Musculin (MSC)

Musculin is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. ABF1 is capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro, and forms heterodimers with E2A proteins in vivo.ABF1 expression was restricted to a subset of lymphoid tissues, lymphoblastoid cell lines, and activated human B cells. The authors suggested that ABF1 is a downstream target of the B-cell receptor signal transduction pathway.