Neural Precursor Cell Expressed, Developmentally Down Regulated 1 (NEDD1)

NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation. Nedd genes are expressed strongly during the early development of the mouse central nervous system but at much reduced levels in adult tissues. The expression and biologic activity of NEDD1 suggests a potential role as a tumor suppressor gene.