PML RARA Regulated Adaptor Molecule 1 (PRAM1)

PRAM1 is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).Sequence analysis predicted that the 718-amino acid PRAM1 protein contains 8 N-terminal proline-rich repeats. Several proline residues are clustered as type I or type II SH3 recognition motifs. The C terminus of PRAM1 has group I SH2 domains as well as an SH3-like domain that is 57% similar to that of FYB.