Phosphatase And Actin Regulator 4 (PHACTR4)

Phosphatase And Actin Regulator 4 is a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene.mouse Phactr4 coprecipitated with both PP1 and actin following expression in human embryonic kidney cells. The PHACTR proteins share highest similarity in sequences surrounding the N- and C-terminal RPEL repeats and in the C-terminal actin- and protein phosphatase-1 (PP1; see 176875)-binding domains. In situ hybridization of rat brain showed Phactr4 highly expressed in periventricular regions, cerebellum, and hippocampus.