Polyamine Modulated Factor 1 Binding Protein 1 (PMFBP1)

Polyamine-modulated factor 1-binding protein 1 is a protein encoded by the PMFBP1 gene. May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton.Cotransfection of PMF1 and NRF2 activated transcription from the polyamine-responsive element of the SSAT promoter in a reporter assay, and PMF1 was the rate-limiting component.Mutations that interrupted either of these regions altered the ability of the proteins to interact, and they lost their ability to regulate transcription of the SSAT gene.