T-Cell Activation Rho GTPase Activating Protein (TAGAP)

By microarray analysis to identify genes coregulated with interleukin-2 (IL2) in a combination of experiments involving T-cell activation and other conditions, followed by RT-PCR, Mao et al. (2004) cloned TAGAP. The 731-amino acid protein contains a RHOGAP domain. Real-time PCR analysis indicated that TAGAP expression peaked approximately 4 to 6 hours after T-cell activation.The International Radiation Hybrid Mapping Consortium mapped the TAGAP gene to chromosome 6 .For discussion of a possible association between variation in the TAGAP gene and celiac disease.For discussion of a possible association between variation in the TAGAP gene and type 1 diabetes, see IDDM21.