Tetraspanin 15 (TSPAN15)

TSPAN15 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene.The deduced 294-amino acid protein contains 4 transmembrane segments and other characteristics of a tetraspanin, including a conserved CCG motif in extracellular domain-2. RT-PCR detected TSPAN15 expression in most human cell lines examined.TSPAN15 gene maps to chromosome 10, between markers D10S210 and D10S537.