Thyroid Hormone Receptor Interactor 12 (TRIP12)

The thyroid hormone receptors (TRs) are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The predicted 1,992-amino acid TRIP12 protein contains a putative transmembrane domain. TRIP12 shares amino acid sequence similarity with the S. cerevisiae YKL010C gene product in 3 regions, with percent identities ranging from approximately 33 to 43%. Northern blot analysis detected TRIP12 expression in all 16 human tissues examined, with the highest expression in skeletal muscle and testis, lower expression in heart, kidney, spleen, thymus, prostate, ovary, placenta, and peripheral blood leukocytes, and the lowest expression in brain, lung, liver, pancreas, small intestine, and colon.