Thyroid Hormone Receptor Interactor 4 (TRIP4)

The thyroid hormone receptors (TRs) are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. They must specifically interact with a number of proteins as they progress from their initial translation and nuclear translocation to heterodimerization with retinoid X receptors (RXRs), functional interactions with other transcription factors and the basic transcriptional apparatus, and eventually, degradation.TRIP4 interacted with rat Thrb only in the presence of thyroid hormone. It also showed a ligand-dependent interaction with RXR-alpha, but did not interact with the glucocorticoid receptor under any condition. TRIP4 contains a putative zinc finger motif with an arrangement of cysteines nearly identical to that of the zinc-binding sequence in the adenovirus E1A transactivator.