Toll Like Receptor Adaptor Molecule 2 (TICAM2)

TIRP is a Toll/interleukin-1 receptor (IL1R) (TIR) domain-containing adaptor protein involved in Toll receptor signaling.The predicted 235-amino acid protein, which is 70% identical to the mouse protein, has a central TIR domain that is most similar to that of TRIF. Northern blot analysis indicated that TIRP is expressed ubiquitously. Transcripts of 3.8, 3.6, and 2.0 kb were detected, and they were differentially expressed in tissues. TIRAP , and TRIF, but not with MYD88, TLR2, or TLR4. Among IRAKs, TIRP interacted with wildtype IRAK2 and IRAKM (IRAK3), both of which lack kinase activity, but it interacted only with kinase-inactive mutants of IRAK1 and IRAK4. Analysis of deletion mutants determined that the TIR domain of TIRP interacted specifically with the TRAF domain of TRAF6; TIRP did not interact with TRAF5.