Triggering Receptor Expressed On Myeloid Cells 4 (TREM4)

Members of the CD300-like family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006). The predicted human proteins contain 222, 233, 298, and 332 amino acids, and all 4 have a signal peptide, an Ig domain, a transmembrane domain, and cytoplasmic tail that is shorter than that found in the mouse Cd300lg isoforms. Northern blot analysis detected a major 3-kb CD300LG transcript that was highly expressed in human heart, skeletal muscle, and placenta and weakly expressed in most other tissues examined; no expression was detected in brain.