B-Cell Scaffold Protein With Ankyrin Repeats Protein 1 (BANK1)

BANK1 is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.The deduced 755-amino acid protein has a calculated molecular mass of 85.5 kD. BANK1 shares amino acid homology with mouse Bcap (PIK3AP1) especially over the ankyrin repeat motifs and predicted coiled-coil regions. BANK1 contains 23 tyrosine residues that may be phosphorylated including several potential SH2 domain binding sites.