BTG3 Associated Nuclear Protein (BANP)

BANP encodes a protein that binds to matrix attachment regions. The protein functions as a tumor suppressor and cell cycle regulator. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.The deduced 509-amino acid mouse protein contains a 42-amino acid insertion compared with the human protein, and except for this insertion, mouse and human BANP share 95% identity. Northern blot analysis of mouse tissues detected high expression in heart, spleen, and thymus, and moderate expression in muscle and bladder. No expression was detected in liver. Banp was expressed in the nucleus of transfected HeLa cells.the mouse Smar1 protein contains a central arginine-serine (RS)-rich domain (amino acids 160 to 350) containing a nuclear localization signal and a serine-rich motif.