Bcl6 Corepressor Like Protein 1 (BCORL1)

BCORL1 is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene. BCORL1 contains a putative bipartite nuclear localization signal, tandem ankyrin repeats, and a classic CTBP-binding motif, PXDLS. BCORL1 shares homology with the BCOR protein, a transcriptional corepressor for the BCL6 transcriptional repressor. The human and mouse BCORL1 proteins are about 80% identical. Northern blot analysis of human tissues detected highest expression of BCORL1 in testis and prostate, medium expression in lymphocytes and spleen, and low expression in many other tissues.