Cytochrome P450 4F22 (CYP4F22)

CYP4F22 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. CYP4F22 is evolutionarily conserved, displays 86% protein homology with rodent orthologs, and exhibits 67% amino acid homology with CYP4F2 and CYP4F3, which are also located in the F subfamily gene cluster on chromosome 19. RT-PCR analysis of human tissues detected high expression in culture keratinocytes and testis with lower expression in placenta, bone marrow, small intestine, liver, skeletal muscle, brain, and kidney.