DnaJ/HSP40 Homolog Subfamily B, Member 5 (DNAJB5)

DNAJB5 belongs to the evolutionarily conserved DNAJ/HSP40 protein family. By searching for sequences similar to bacterial Dnaj, followed by PCR amplification, Chen et al. (1999) obtained a partial human DNAJB5 clone, which they called HSC40. They cloned full-length mouse Dnajb5, which encodes a deduced 462-amino acid protein. Northern blot analysis of human tissues detected ubiquitous expression of DNAJB5, with highest levels in heart, followed in order by skeletal muscle, spleen, liver, brain, and pancreas, and very weak expression in lung and kidney.This expression pattern is similar to that of HSC70 (HSPA8) but different from that of HSP40 (DNAJB1), which is low under normal growth conditions and significantly induced by heat shock or sodium arsenite.