DnaJ/HSP40 Homolog Subfamily C, Member 10 (DNAJC10)

The deduced 793-amino acid protein has a calculated molecular mass of about 91 kD. ERDJ5 contains an N-terminal hydrophobic sequence, followed by a type III DnaJ domain, 4 thioredoxin-like domains, and a C-terminal KDEL endoplasmic reticulum (ER) retention signal. Northern blot analysis detected a major 4.4-kb transcript in all tissues examined. Highest levels were in pancreas and testis, and intermediate levels were in heart, liver, spleen, prostate, and ovary. Several smaller transcripts were also observed. In situ hybridization in mice detected strong expression in prostate; adrenal cortex and medulla; several areas of the central nervous system, particularly neurons of the hippocampus and granular cell layer of the cerebellar cortex; epididymis; stratified epithelium of the alimentary tract; and intestinal mucosa.