Enkurin (ENKUR)

Enkurin interacts with transient receptor potential canonical (TRPC) cation channels and functions as an adaptor protein, tethering signal transduction proteins to TRPC channels . Enkurin is lysine-rich and has an N-terminal proline-rich region, which contains SH3 domain ligand sequences, and a C-terminal IQ motif. Northern blot analysis of human tissues detected strong expression in testis. Mouse enkurin was detected as a 25-kD band in mouse sperm extracts. Northern blot analysis of mouse tissues detected strong expression in testis and vomeronasal organ, with lower expression in ovary, heart, lung, and brain. Enkurin localized in or near the developing acrosome in postmeiotic mouse spermatids and to the acrosomal crescent and flagellar principal piece in mouse sperm, colocalizing with TRPC channels.