Feline Leukemia Virus Subgroup C Cellular Receptor 2 (FLVCR2)

The FLVCR2 gene encodes a transmembrane protein that belongs to the major facilitator superfamily of secondary carriers that transport small solutes in response to chemiosmotic ion gradients, such as calcium .The deduced 527-amino acid protein contains 12 transmembrane domains and the N- and C-terminal domains are cytoplasmic.All transcripts encode a deduced 526-amino acid protein that has an N-terminal hexad repeat, 6 extracellular loops, and a C-terminal polyglutamate sequence. EST analysis detected CCT in brain, heart, kidney, lung, placenta, uterus, cervix, prostate, testis, germ cells, and whole fetus. Immunofluorescence analysis of human pituitary detected CCT predominantly in acidophils.