Frequently Rearranged In Advanced T-Cell Lymphomas 1 (FRAT1)

FRAT1 belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis.The gene Frat1 was identified as one that was frequently mutated by proviral insertion during later stages of T-cell lymphomagenesis. Mouse Frat1 is an intronless gene that encodes a predicted 274-amino acid protein. Overexpression of Frat1 in lymphoma cells that overexpressed Myc and Pim1 conferred a selective advantage.GSK3-binding and -inhibitory activities of Xenopus GBP and human FRAT2 reside in the C-terminal conserved domain III sequence, which is shared with FRAT1. The authors proposed that GBP, FRAT1, and FRAT2 form a family of GSK3-binding proteins that inhibit the phosphorylation of beta-catenin, preventing its degradation by the ubiquitin-proteasome pathway.