GA Binding Protein Transcription Factor Beta (GABPb)

GABPb encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. The predicted GABPB1 and GABPB2 subunits contain 383 and 347 amino acids, respectively, and are highly homologous. The N-terminal 332 amino acids of GABPB1 and GABPB2, including 4 tandemly repeated Notch motifs, are identical; the proteins differ at their C termini.