Gibbon Ape Leukemia Virus Receptor 1 (GLVR1)

Retrovirus receptors allow infection of human and murine cells by various retroviruses. The receptors that have been identified at the molecular level include CD4 for human immunodeficiency virus, Rec1 for murine ecotropic virus, and GLVR1 for gibbon ape leukemia virus. These 3 proteins show no homology to one another at the DNA or protein level. GLVR1 is a sodium-dependent phosphate symporter.By expression in Xenopus oocytes and in mammalian cells, Kavanaugh et al. (1994) determined that GLVR1 is a sodium-dependent phosphate symporter. Voltage-clamp analysis indicated net cation influx, suggesting that phosphate is transported with excess sodium ions.