Guanylate Binding Protein 3 (GBP3)

GBP3 encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts with a member of the germinal center kinase family. Olszewski et al. (2006) reported that the 595-amino acid GBP3 protein shares 88% and 76% identity with GBP1 and GBP2, respectively. All GBPs, including GBP3, have a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T(L/V)RD sequence not found in other GTPases. GBP3 lacks the C-terminal CaaX isoprenylation motif found in GBP1, GBP2, and GBP5. EST database analysis indicated wide expression of GBP3 in human tissues.