HIV1 Rev Binding Protein Like Protein (HRBL)

HRBL is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. The predicted 481-amino acid RABR protein shares 46% identity with RAB. Both RAB and RABR contain a zinc finger region near the N terminus, several phe-gly (FG) motifs characteristic of nucleoporin-like proteins, and 4 NPF motifs located in the C-terminal half.