High Mobility Group Box Protein 3 (HMGB3)

HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 and HMG2 , HMGB3 contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box subfamily are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription .Vaccari et al. (1998) isolated mouse and human cDNAs corresponding to HGM2A, which they called HMG4. They reported that the deduced mouse and human proteins contain 200 amino acids and are 97% identical. Northern blot and RT-PCR analyses suggested that mouse Hmg4 transcripts are much more abundant in embryonic than in adult tissues. Hmgb3 was preferentially expressed in mouse hematopoietic stem cells (HSCs) and that it was expressed in adult mouse bone marrow cells.