High Mobility Group Nucleosome Binding Domain Protein 4 (HMGN4)

HMGN4 is a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Transcript variants utilizing alternative polyadenylation signals exist for this gene.HMGNs are members of the High mobility group of chromosomal proteins that help with transcription, replication, recombination, and DNA repair.HMGNs are non-histone proteins, which associate with nucleosomes to control transcription of genes. HMGNs control transcription by altering the interaction of histone H1 with nucleosomes to maintain a decondensed chromatin structure.