Host Cell Factor C2 (HCFC2)

Host Cell Factor C2 is one of two proteins which interact with VP16,a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described.Northern blot analysis revealed wide expression of a major 3.2-kb transcript and minor 4.9- and 7.0-kb transcripts, with highest expression in testis. Only the major transcript was expressed in peripheral blood. Immunofluorescence analysis demonstrated predominantly cytoplasmic expression of HCF2.