Interferon Gamma Inducible Protein 30 (IFI30)

Gamma-interferon-inducible lysosomal thiol reductase is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.Arunachalam et al. (2000) described a lysosomal thiol reductase, which they called GILT, that was optimally active at low pH and capable of catalyzing disulfide bond reduction both in vivo and in vitro. They found that the GILT gene encodes a predicted 261-amino acid protein composed of a 37-amino acid signal peptide and a 224-amino acid proform.