Interleukin 17 Receptor C (IL17RC)

Interleukin-17 receptor C is a single-pass transmembrane protein that shares limited similarity with the interleukin-17 receptor. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only three have been determined to date.The predicted full-length 720-amino acid protein has an N-terminal signal peptide, followed by an acidic extracellular domain with 9 potential N-glycosylation sites, a single-pass transmembrane domain, and a basic cytoplasmic region with multiple phosphorylation sites. It has a calculated molecular mass of 76.4 kD and shares 22% amino acid identity with IL17R.strongest expression in prostate, kidney, liver, heart, and muscle, with barely detectable levels in thymus and peripheral blood leukocytes.