Leukotriene B4 Receptor (LTB4R)

Using degenerate PCR to find cDNAs encoding new G protein coupled-receptors in human B cells, Owman et al. (1996) identified a CMKRL1 cDNA which encodes a 352-amino acid polypeptide with a calculated mass of 43 kD. The nearest homologs of this novel sequence are the chemoattractant leukocyte receptors, such as the C5a anaphylatoxin receptor and the FMLP receptor. Northern blot analysis revealed transcripts of 5 kb and 7.5 kb in several tissues of the immune system including spleen, thymus, and lymph node. Owman et al. (1996) considered the high level of expression in lymphoid tissues suggestive of the role of CMKRL1 in the regulation of the inflammatory system.