Myeloid/Lymphoid Or Mixed Lineage Leukemia 2 (MLL2)

MLL2 is a striking example with 24 amino acid runs, all but 2 of which are glutamine runs. The gene encodes a 5,262-amino acid protein containing a SET domain, 5 PHD fingers, potential zinc fingers, and a long run of glutamines interrupted by hydrophobic residues (mostly leucine). They also detected an alternatively spliced form encoding 4,957 amino acids and lacking an N-terminal zinc finger and PHD finger. Analysis of ALR expression showed that its approximately 18-kb transcript is expressed, like ALL1, in most adult tissues, including a variety of hematopoietic cells, but not in liver. Whole mount in situ hybridization of early mouse embryos indicated expression of a similar mouse gene in multiple tissues.