Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2)

NFATC2 is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.A truncated form of NFATP, expressed as a recombinant protein in bacteria, bound specifically to the NFAT site of the murine IL2 promoter and formed a transcriptionally active complex with recombinant FOS and JUN.