Proline Rich G Carboxyglutamic Acid 1 (PRRG1)

PRRG1 encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. Unlike all other known Gla domain-containing proteins, PRRG1 lacks a discernible signal peptide. The authors stated that PRRG1 is likely oriented with its C terminus in the cytoplasm.