Proline Rich Protein 7, Synaptic (PRR7)

Proline-rich proteins (PRPs) is a class of intrinsically unstructured proteins (IUP) containing several repeats of a short proline-rich sequence.Many tannin-consuming animals secrete a tannin-binding protein (mucin) in their saliva. Tannin-binding capacity of salivary mucin is directly related to its proline content. Proline Rich 7 found in a postsynaptic membrane complex with DLG4 and GRIN1. Interacts with DLG4. Interacts preferentially to the PDZ3 domain of DLG4 and to lesser degree to PDZ2 but not to the PDZ1. Subcellular location: Membrane; Single-pass type III membrane protein (Potential). Cell junction, synapse, postsynaptic. Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern