Regenerating Islet Derived Protein 1 Beta (REG1b)

Lithostathine-1-beta is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandomly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. The proteins encoded by REG1A and REG1B comprised 166 amino acids and differed by only 22 amino acids. The expression of REG1B was observed in pancreas and liver.