Small Proline Rich Like Protein 1A (SPRL1A)

By database analysis to identify human orthologs of mouse genes encoding late envelope proteins (LEPs), Marshall et al. (2001) identified LCE2D, which they called LEP12.Using real-time PCR, Jackson et al. (2005) detected low LCE2D expression in human fetal, arm, penal, and abdominal skin, as well as in vulva and esophagus, but not in tongue.Jackson et al. (2005) showed that expression of LCE2 genes, including LCE2D, was upregulated in cultured normal human keratinocytes by both ultraviolet irradiation and calcium. Jackson et al. (2005) determined that the LCE2D gene contains 2 exons. Exon 1 is noncoding.By genomic sequence analysis, Marshall et al. (2001) mapped the LCE2D gene within the LCE gene cluster on chromosome 1q21. Jackson et al. (2005) stated that the mouse Lce2d gene maps to a syntenic LCE gene cluster on chromosome 3F1.